RISE UP study asks: could PAP treatment transform the recovery process after stroke? And, ultimately, reduce the chances of another stroke?
Rebecca Hankla and Lauren Waggoner, PhD
Nox Health is serving on the investigative team for the Recovery in Stroke Using Positive Airway Pressure (PAP) study, also known as the RISE UP study. Our participation in the RISE UP study is similar to our role in the Sleep SMART trial (see Sleep SMART trial looking at the effect of OSA treatment on stroke patients).
Both trials are looking at the effects of PAP therapy treatment for obstructive sleep apnea (OSA) in patients who have recently had a stroke or transient ischemic attack (TIA) and have a moderate to severe OSA diagnosis. Ischemic stroke affects 700,000 individuals annually in the U.S. and is the leading cause of long-term disability in adults. Researchers are considering new therapeutic approaches to transform the recovery process.
Real world component
While there are many similarities between the two studies, the RISE UP study adds a “real world” component: subacute treatment. Some patients will start PAP therapy one week after the onset of stroke symptoms (acute intervention). Another segment will begin therapy one month following symptoms, which approximates the time frame patients normally experience getting sleep apnea care in today’s healthcare system. The goal of both studies is to see if PAP treatment can limit stroke severity, complement or even enhance other forms of rehabilitation and, ultimately, improve recovery and reduce the chances of another stroke.
RISE UP study
In the RISE UP study, patients who receive PAP treatment are assigned a care manager who supports them and facilitates care for six months. At the end of the trial, subjects will undergo clinical assessments of physical and cognitive function. Half of the subjects will participate in in-depth interviews to understand the patient and caregiver experience with PAP and, specifically, factors that influence adherence.
As with the Sleep SMART trial, the Nox Health Clinical Science and Applied Analytics team is overseeing all tele-sleep diagnostic testing, OSA treatment with CPAP, and technology-enabled medical and behavioral therapy support. By applying our clinical science approach to OSA, along with expertise in tele-sleep diagnostics, treatment and medical and behavioral management, the team hopes our innovative sleep health care model will promote better recovery for stroke patients.
The RISE UP study is sponsored by Yale University and funded through the National Institute of Health’s National Institute of Nursing Research.
Sources: Redeker, N et al. (2021) National Institutes of Health, The Recovery in Stroke Using PAP (RISE UP) Study https://grantome.com/grant/NIH/R01-NR018335-01
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